Evaluation of gargling Cololo solution for bacterial growth inhibition
박아영, 강아영, 박찬영, Hong Seung-Hye, Lee Dae-Yoon, 이윤재, 정석률, 신호준,
소속 상세정보
박아영 ( Park A-Young ) - Namseoul University School of Health and Medicine Department of Biomedical Laboratory Science
강아영 ( Kang A-Young ) - Namseoul University School of Health and Medicine Department of Biomedical Laboratory Science
박찬영 ( Park Chan-Young ) - Namseoul University School of Health and Medicine Department of Biomedical Laboratory Science
( Hong Seung-Hye ) - Namseoul University School of Health and Medicine Department of Biomedical Laboratory Science
( Lee Dae-Yoon ) - Namseoul University School of Health and Medicine Department of Biomedical Laboratory Science
이윤재 ( Lee Yun-Jae ) - Namseoul University School of Health and Medicine Department of Biomedical Laboratory Science
정석률 ( Jung Suk-Yul ) - Namseoul University School of Health and Medicine Department of Biomedical Laboratory Science
신호준 ( Shin Ho-Joon ) - Ajou University School of Medicine Department of Microbiology
KMID : 0353320150390020155
Abstract
Purpose: The aims of this study were to analyze whether or not Cololo SP solution developed in Japan could be an alternative or superior to Hexamedine solution.
Materials and Methods: Analysis was done by evaluating the bactericidal effects of mouthwash. Several methodologies tested, e.g., mixing bacteria directly into the mouthwash and long-term treatment of bacteria with solution.
Results: Bacterial suspension treated twice with 80-fold diluted Cololo SP solution (1 hour of incubation at room temperature [RT] and 4 hours of incubation at RT) was more effective than single-directed inoculation of bacteria mixed with Cololo SP solution.
Conclusion: The recommended dosage for Hexamedine solution application is two times for 1 min/d, and application should not be continued for more than 2 weeks. Thus, a new therapy needs to be developed to facilitate its continuous application as a mouthwash. Hexamedine solution is generally harmful if used for even 10 days. Therefore, our data suggest that Cololo SP solution would be a better alternative to Hexamedine solution.
키워드
Bacterial inhibition; Cololo SP solution; Hexamedine
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